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The hot plate test is a test of the pain response in animals, similar to the tail flick test. It is used in basic pain research and in testing the effectiveness of analgesics by observing the reaction to pain caused by heat. It was proposed by Eddy and Leimbach in 1953. They used a behavioral model of nociception where behaviors such as jumping and hind paw-licking are elicited following a noxious thermal stimulus. Licking is a rapid response to painful thermal stimuli that is a direct indicator of nociceptive threshold. Jumping represents a more elaborated response, with a latency, and encompasses an emotional component of escaping. ==Procedure== *A transparent glass cylinder is used to keep the animal on the heated surface of the plate. *The temperature of the hot plate is set using a thermoregulated water-circulated pump. *The time of latency is defined as the time period between the zero point, when the animal is placed on the hot plate surface, and the time when the animal licks its paw or jumps off to avoid thermal pain.〔Ripoll N, Hascoet M, Bourin M. The four-plates test: Anxiolytic or analgesic paradigm? Progress in Neuro-Psychopharmacology and Biological Psychiatry, July 2006 vol. 30 issue 5, 873-880.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「hot plate test」の詳細全文を読む スポンサード リンク
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